Polynucleotides & Skin Boosters

What are Polynucleotides?

Polynucleotides are injectable biostimulators made from highly purified DNA fragments. Unlike traditional treatments that simply coat or "fill" the skin, polynucleotides work at a cellular level to repair damaged tissue, boost collagen production, and improve skin quality from the inside out.

How do they work?

They act as "messengers" for your cells. When injected, they stimulate fibroblasts (the cells responsible for skin structure) to produce more collagen and elastin. They also have powerful anti-inflammatory properties and help the skin retain its own natural moisture.

Is there any downtime?

Downtime is minimal. You may experience:

  • Small, visible bumps at the injection sites (usually disappear w/in 24–48 H)

  • Mild swelling or redness.

  • The possibility of minor bruising, especially in the delicate eye area.

How many sessions are required?

Regenerative medicine is a journey. For best results, a course of 3 treatments spaced 3–4 weeks apart is typically recommended. Results develop gradually as your collagen stores replenish.

Are they the same as Dermal Fillers?
  • Fillers add volume and "plump" a specific area physically.

  • Polynucleotides do not add artificial volume; they improve the actual health and thickness of your skin. They are often called "biological primers."

Are there any contraindications?

Because the DNA fragments are ethically sourced from fish, this treatment is not suitable for those with a severe fish or seafood allergy.

It is also not recommended for those who are pregnant or breastfeeding.

Why are they so popular for the eye area?

The skin around the eyes is the thinnest on the body. Polynucleotides are ideal for this area because they:

  • Strengthen the skin to reduce "crepiness."

  • Improve microcirculation to help fade dark circles.

  • Reduce fine lines (crow's feet) without the risk of puffiness or "water retention" that can occur with hyaluronic acid.

What other areas can be treated?

While the eyes are a primary focus, they are highly effective for:

  • Full face rejuvenation (glow and firmness).

  • Neck and décolletage (thin, sun-damaged skin).

  • Scarring (including acne scars).

  • The backs of the hands.

Skin Boosters

What are Skin Boosters?

Skin boosters are injectable treatments—usually formulated with Hyaluronic Acid (HA)—designed to deliver deep-level hydration. They aren't meant to change your face shape; they are designed to give you a "lit-from-within" glow, improve elasticity, and smooth out fine surface lines.

How do they differ from Polynucleotides?
  • Skin Boosters (Hydration Focus): Act like a sponge, pulling water into the skin for an immediate "plump" and dewy finish.

  • Polynucleotides (Repair Focus): Act like a biological signal, telling your cells to fix themselves and grow new tissue.

Will they make my face look puffy?

No. Unlike traditional dermal fillers, skin boosters have a very fluid consistency. They spread evenly under the skin rather than staying in one spot to add volume. You’ll look refreshed.

What can I expect to see?
  • The "Glow": A visible increase in skin radiance and luminosity.

  • Smoothness: A reduction in "crepey" skin and fine dehydration lines.

  • Elasticity: Skin that feels firmer and "snaps back" more easily.

The treatment usually takes about 20–30 minutes.

When do the results show up?

You may see a "boost" in hydration within 48 hours, but the full effect—when the skin starts producing its own extra collagen in response—usually peaks at 3–4 weeks.

How long do they last?

Depending on the specific brand and your lifestyle (hydration, sun exposure, smoking), results typically last between 6 to 9 months.

Is there downtime?

Downtime is minimal, but you should expect:

  • Tiny Bumps: Small "blebs" at the injection sites that look like bee stings. These usually vanish within 24 hours as the product absorbs.

  • Bruising: Occasional minor bruising

How long does it take?
What aftercare is needed?

To get the best results, avoid the following for 24–48 hours:

  • Strenuous exercise (sweating can irritate injection sites).

  • Saunas, steam rooms, and hot power showers.

  • Applying makeup (to prevent infection).

  • Alcohol (which can increase the risk of bruising).

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aesthetique@equaligne.com